Tuesday, 9th September CD1-MR1 Workshop 2025

Additional Chairs: Lydia Lynch, Branch Moody, Dan Pellicci and Corinna Kulicke

• The emerging role of MAIT cells and broader MR1-reactive T cell Immunity - James McCluskey

•  Exposure to Mycobacteria Shapes the Phenotype and TCR Repertoire of MR1Ts - David Lewinsohn

• Using Cellular CD1 Ligands to Design Lipid Inhibitors of Skin Inflammation - Branch Moody
• Identification of conserved CD1b motif (RExxD) that interacts with TRBV4-1 - Minori Asa
• Acetoacetate suppresses colon cancer via an MR1-MAIT axis - Slater L Clay
• Agilent and Panome Bio Talk - Speaker To Be Announced

• CD1a-reactive T cells and the skin: therapeutic potential of inhibition - Graham Ogg
• Calcium signaling in MR1 presentation of Mycobacterium tuberculosis infection - Elly Karamooz
• MAIT cell responses to intracellular and extracellular pathogens are mediated by distinct antigen presenting cells - Michael G. Constantinides

• A little bit on the side - Jamie Rossjohn
• Optimisation of NKT cell-mediated adjuvant activity for mRNA vaccines - Gavin Painter
• The antigen presenting molecule MR1 binds riboflavin catabolites - Wael Awad

• Patient-derived pancreatic tumor bacteria exhibit oncogenic properties and are recognized by MAIT cells in tumor spheroids - Michał J Sobkowiak
• Advances in the characterisation of antigen presentation by group 1 CD1 antigen-presenting molecules - Adam Shahine
• Understanding the molecular basis of autoreactive T cell recognition of CD1a presenting self-lipid antigen - Jia Jia Lim
• Investigating the role of CD1a and CD1d in Nickel Allergic Contact Dermatitis  - Aoife Clancy
• Generative Diffusion-Based De Novo Protein Design of Lipid/CD1-Restricted TCR Mimics - Andrew McShan
• Small molecules from conserved metabolic pathways form alternate 5-A-RU-based MR1 ligands that are recognised by MAIT cells - Michael NT Souter
• Antibody-dependent cellular cytotoxicity of iPS cell-derived natural killer T cells by anti-GD2 mAb for neuroblastoma - Katsuhiro Nishimura
• Characterization of bile acids as novel MR1 ligands - Alejandro Briones-Contreras

• Molecular insights into the capability of the MR1 molecule to display host-derived metabolites for T cell surveillance - Wael Awad
• Proximal tubule CD1d and natural killer T-cells in acute cardiorenal syndrome - Kevin G Burfeind
• DEVELOPMENT OF REJECTION-RESISTANT ALLOGENEIC CAR-NKT CELL THERAPY FOR CD19-POSITIVE B CELL MALIGNANCIES  - Kshiti Dholakia
• High throughput discovery approaches identify human self-metabolites of several chemical classes as antigens for MAIT cells - Iria Gomez-Tourino
• Activated MAIT cells drive fibrosis in primary sclerosing cholangitis in a SPARC dependent manner - Florencia Gutierrez
• Analysis of collaborative cross mouse strains to identify genes differentially involved in MAIT versus NKT cell thymic development - Emi Ito
• Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens - Se-Jin Kim
• Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens - Corinna A Kulicke
• Development of a sensitive, scalable assay for MR1-bound 5-OP-RU - Martin Lett
• Investigating the molecular basis by which antigens are loaded onto different MR1 variants - Victoria Letoga
• Discovering isoform-specific lipidomic signatures associated with human CD1 proteins - Shuqi Li
• Understanding the Molecular Mechanism of Recognition of Bacteroides fragilis produced glycosphingolipids by Natural Killer T (NKT) cell Receptors - Vasudha Maddali
• Metabolomic analysis of mammalian-derived MR1-ligands - Edward J Mathias
• Probing CD1d mediated lipid specific iNKT interactions in solution - Uri Z Miles
• Identification of self-metabolites as MR1 ligands and autoantigens in Type 1 diabetes - Lucía Mosquera-Ferreiro
• Allelic variation of MR1 shapes its antigen repertoire and presentation capacity - Adam G Nelson
• TCR-dependent MAIT cell activation controls visual function - Kensuke Shibata
• NAADP-mediated endosomal calcium signaling enables MR1 presentation of Mycobacterium tuberculosis - Allison Tammen
• Multimodal profiling of phosphomycoketide-reactive γδ T cells in BCG-vaccinated South African infants - Tori Tappen
• Deciphering the molecular basis of headless lipid recognition by NKT cells   - Praveena Thirunavukkarasu
• Crohn’s disease-Associated Invariant T (CAIT) cells from Crohn’s disease patients are activated by hydrophobic antigens in human ileum - Ildiko Van Rhijn
• Allogeneic NKT Cells Expressing a CD19-specific CAR in Patients with Relapsed or Refractory B cell Malignancies: an Interim Analysis - Leonid Metelitsa